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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAPT All Species: 18.18
Human Site: S721 Identified Species: 44.44
UniProt: P10636 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P10636 NP_001116538.1 758 78878 S721 P V V S G D T S P R H L S N V
Chimpanzee Pan troglodytes Q5YCW1 776 80960 S739 P V V S G D T S P R H L S N V
Rhesus Macaque Macaca mulatta P57786 459 47954 P423 V V S G D T S P R H L S N V S
Dog Lupus familis XP_850032 783 81479 S746 P V V S G D T S P R H L S N V
Cat Felis silvestris
Mouse Mus musculus P10637 733 76225 S696 P V V S G D T S P R H L S N V
Rat Rattus norvegicus P19332 752 78545 S715 P V V S G D T S P R H L S N V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517812 273 28571 P237 T V S G D S S P Q R L S N V S
Chicken Gallus gallus XP_424354 421 43925 P385 T I S G D A S P R R L S N V S
Frog Xenopus laevis NP_001082230 673 71638 P637 G H S G E T S P R R L S N V S
Zebra Danio Brachydanio rerio XP_001919266 309 32052 P273 D I S T D G S P R R L S N V S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.9 56 81 N.A. 74.5 74.4 N.A. 32.8 47.7 39.3 29.1 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 97 57.7 83.7 N.A. 80.8 80.2 N.A. 34.8 51.3 53.2 36.4 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 6.6 100 N.A. 100 100 N.A. 13.3 6.6 6.6 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 20 100 N.A. 100 100 N.A. 26.6 26.6 20 33.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 0 0 0 40 50 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 10 0 0 40 50 10 0 0 0 0 0 0 0 0 0 % G
% His: 0 10 0 0 0 0 0 0 0 10 50 0 0 0 0 % H
% Ile: 0 20 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 50 50 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 50 50 0 % N
% Pro: 50 0 0 0 0 0 0 50 50 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 40 90 0 0 0 0 0 % R
% Ser: 0 0 50 50 0 10 50 50 0 0 0 50 50 0 50 % S
% Thr: 20 0 0 10 0 20 50 0 0 0 0 0 0 0 0 % T
% Val: 10 70 50 0 0 0 0 0 0 0 0 0 0 50 50 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _